Simoctocog alfa
Nuwiq, Vihuma (simoctocog alfa) is a protein pharmaceutical. Simoctocog alfa was first approved as Nuwiq on 2014-07-22. It is used to treat factor VII deficiency, hemophilia a, hemorrhage, and von willebrand diseases in the USA. It has been approved in Europe to treat hemophilia a.
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354 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemophilia a | D006467 | EFO_0007267 | D66 | 42 | 36 | 105 | 49 | 107 | 316 |
| Hemophilia b | D002836 | — | D67 | 2 | 2 | 11 | 1 | 10 | 25 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 5 | 1 | 6 | 3 | 6 | 20 |
| Hemostatic disorders | D020141 | — | — | 5 | 1 | 6 | 3 | 6 | 20 |
| Von willebrand diseases | D014842 | EFO_0003910 | D68.0 | 1 | 2 | 12 | 3 | 2 | 19 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 3 | 3 | 3 | 9 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | 1 | 1 | 2 | 2 | 6 |
| Inherited blood coagulation disorders | D025861 | — | — | — | — | — | 1 | 2 | 3 |
| Recurrence | D012008 | — | — | — | — | — | 1 | 2 | 3 |
| Immune tolerance | D007108 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Deficiency diseases | D003677 | EFO_1001067 | E63 | — | — | 1 | — | 1 | 2 |
| Hemorrhagic disorders | D006474 | — | D69.9 | — | — | 1 | — | 1 | 2 |
| Bone diseases | D001847 | — | M89.9 | — | — | 1 | — | — | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | 1 | — | — | — | 5 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | 3 | 4 |
| Genetic therapy | D015316 | — | — | 1 | 1 | — | — | 1 | 2 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34.0 | — | 1 | — | — | — | 1 |
| Diffuse scleroderma | D045743 | EFO_0000404 | — | — | 1 | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 3 von willebrand disease | D056729 | Orphanet_166096 | D68.03 | 1 | — | — | — | 1 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | — | — | 3 | 3 |
| Coagulation protein disorders | D020147 | — | — | — | — | — | — | 2 | 2 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | — | — | 1 | 1 |
| Replacement arthroplasty | D019643 | — | — | — | — | — | — | 1 | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 1 | 1 |
| Hemolysis | D006461 | — | — | — | — | — | — | 1 | 1 |
| Hemolytic anemia | D000743 | — | D55-D59 | — | — | — | — | 1 | 1 |
| Inborn genetic diseases | D030342 | EFO_0000508 | — | — | — | — | — | 1 | 1 |
| X-linked genetic diseases | D040181 | — | — | — | — | — | — | 1 | 1 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Simoctocog alfa |
| INN | simoctocog alfa |
| Description | Factor VIII is a medication used to treat and prevent bleeding in people with hemophilia A and other causes of low factor VIII. Certain preparations may also be used in those with von Willebrand's disease. It is given by slow injection into a vein.
|
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | 1300486 |
| ChEMBL ID | CHEMBL2108319 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | P89DR4NY54 (ChemIDplus, GSRS) |
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56 adverse events reported
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